PDBsum entry 5dqo

Replication

PDB id: 5dqo

Contents

Protein chains

158 a.a.

159 a.a.

Ligands

SF4 ×4

Waters ×14

PDB id:

5dqo

Name:

Replication

Title:

Crystal structure of y347f mutant of human primase p58 iron-sulfur cluster domain

Structure:

DNA primase large subunit. Chain: a, b, c, d. Fragment: p58c domain (unp residues 272-464). Synonym: DNA primase 58 kda subunit, p58. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: prim2, prim2a. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.30Å R-factor: 0.252 R-free: 0.275

Authors:

L.E.Salay,M.K.Thompson,W.J.Chazin

Key ref:

E.O'Brien et al. Redox state of the p58c 4fe-4s cluster controls DNA b affinity of human DNA primase. To be published, . PubMed id: 28232525

Date:

15-Sep-15 Release date: 21-Sep-16

Protein chains

P49643  (PRI2_HUMAN) -  DNA primase large subunit from Homo sapiens

Seq: 509 a.a.

Struc: 158 a.a.*

Protein chain

P49643  (PRI2_HUMAN) -  DNA primase large subunit from Homo sapiens

Seq: 509 a.a.

Struc: 159 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.2.7.7.- - ?????