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PDBsum entry 5dp6
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Hydrolase/hydrolase inhibitor
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PDB id
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5dp6
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Crystal structure of ev71 3c proteinase in complex with compound 7
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Structure:
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3c proteinase. Chain: a, b, c, d. Engineered: yes
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Source:
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Enterovirus a71. Organism_taxid: 39054. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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3.01Å
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R-factor:
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0.231
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R-free:
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0.279
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Authors:
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C.Wu,L.Zhang,P.Li,Q.Cai,X.Peng,N.Li,Y.Cai,J.Li,T.Lin
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Key ref:
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C.Wu
et al.
(2016).
Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71.
Biochim Biophys Acta,
1860,
1299-1307.
PubMed id:
DOI:
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Date:
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12-Sep-15
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Release date:
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30-Mar-16
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PROCHECK
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Headers
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References
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A9XG43
(A9XG43_HE71) -
Genome polyprotein from Human enterovirus 71
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Seq:
Struc:
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2193 a.a.
178 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class 2:
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E.C.2.7.7.48
- RNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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diphosphate
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Enzyme class 3:
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E.C.3.4.22.28
- picornain 3C.
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Reaction:
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Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 4:
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E.C.3.4.22.29
- picornain 2A.
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Reaction:
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Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 5:
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E.C.3.6.1.15
- nucleoside-triphosphate phosphatase.
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Reaction:
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
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ribonucleoside 5'-triphosphate
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+
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H2O
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=
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ribonucleoside 5'-diphosphate
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+
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phosphate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Biochim Biophys Acta
1860:1299-1307
(2016)
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PubMed id:
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Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71.
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C.Wu,
L.Zhang,
P.Li,
Q.Cai,
X.Peng,
K.Yin,
X.Chen,
H.Ren,
S.Zhong,
Y.Weng,
Y.Guan,
S.Chen,
J.Wu,
J.Li,
T.Lin.
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ABSTRACT
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Links
