PDBsum entry 4zse

Transferase

PDB id: 4zse

Contents

Protein chains

297 a.a.

313 a.a.

Ligands

ANP ×4

EDO

Metals

_MG ×4

Waters ×798

PDB id:

4zse

Name:

Transferase

Title:

Crystal structure of egfr 696-1022 t790m/v948r, crystal form ii

Structure:

Epidermal growth factor receptor. Chain: a, b, c, d. Fragment: unp residues 695-1022. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

1.97Å R-factor: 0.191 R-free: 0.213

Authors:

X.E.Yan,C.H.Yun

Key ref:

H.Wu et al. Ibrutinib selectively and irreversibly targets egfr-M non-Small cell lung cancer cells. To be published, .

Date:

13-May-15 Release date: 15-Jun-16

Protein chains

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 297 a.a.*

Protein chains

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 313 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] (Bound ligand (Het Group name = ANP) matches with 81.25% similarity) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site