PDBsum entry 4zr8

Lyase

PDB id: 4zr8

Contents

Protein chains

353 a.a.

Ligands

EDO ×6

Metals

_CL ×2

_MG

Waters ×805

PDB id:

4zr8

Name:

Lyase

Title:

Structure of uroporphyrinogen decarboxylase from acinetobacter baumannii

Structure:

Uroporphyrinogen decarboxylase. Chain: a, b. Synonym: uro-d. Engineered: yes

Source:

Acinetobacter baumannii ab5075. Organism_taxid: 1116234. Gene: heme, a591_a1129. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.50Å R-factor: 0.131 R-free: 0.161

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

J.Abendroth et al. Structure of uroporphyrinogen decarboxylase from acinetobacter baumannii. To be published, .

Date:

11-May-15 Release date: 03-Jun-15

Protein chains

A0A0M3KL37  (A0A0M3KL37_ACIBA) -  Uroporphyrinogen decarboxylase from Acinetobacter baumannii AB5075

Seq: 357 a.a.

Struc: 353 a.a.

Enzyme reactions

• Enzyme class: E.C.4.1.1.37 - uroporphyrinogen decarboxylase.
• Pathway: Porphyrin Biosynthesis (later stages)
• Reaction: uroporphyrinogen III + 4 H⁺ = coproporphyrinogen III + 4 CO2

uroporphyrinogen III + 4 × H(+) = coproporphyrinogen III (Bound ligand (Het Group name = EDO) matches with 40.00% similarity) + 4 × CO2

Molecule diagrams generated from .mol files obtained from the KEGG ftp site