PDBsum entry 4zqh

Oxidoreductase

PDB id: 4zqh

Contents

Protein chains

408 a.a.

Ligands

NDP ×2

FOM ×2

GOL ×5

NHE ×2

Metals

_MG ×2

Waters ×162

PDB id:

4zqh

Name:

Oxidoreductase

Title:

Crystal structure of dox-p reductoisomerase in complex with NADPH, fosmidomycin and magnesium

Structure:

1-deoxy-d-xylulose 5-phosphate reductoisomerase. Chain: a, b. Synonym: dxp reductoisomerase,1-deoxyxylulose-5-phosphate reductoisomerase,2-c-methyl-d-erythritol 4-phosphate synthase. Engineered: yes

Source:

Moraxella catarrhalis. Organism_taxid: 480. Gene: dxr, dr90_1378. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.40Å R-factor: 0.204 R-free: 0.243

Authors:

R.W.Birkinshaw,R.L.Brady

Key ref:

R.W.Birkinshaw and r.l.brady Crystal structures of the moraxella catarrhalis dox-P reductoisomerase. To be published, .

Date:

10-May-15 Release date: 29-Jun-16

Protein chains

A0A076U3E6  () -

Enzyme reactions

• Enzyme class: E.C.1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
• Reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP⁺ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H⁺

2-C-methyl-D-erythritol 4-phosphate (Bound ligand (Het Group name = GOL) matches with 46.15% similarity) + NADP(+) (Bound ligand (Het Group name = NDP) corresponds exactly) = 1-deoxy-D-xylulose 5-phosphate + NADPH + H(+)

• Cofactor: Mg(2+) or cobalt cation or Mn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site