PDBsum entry 4zqf

Oxidoreductase

PDB id

4zqf

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Contents

			Protein chains

					402 a.a.

			Ligands

					FOM ×2

			Metals

					_MG ×2

			Waters ×176

PDB id:

4zqf

Links

Name:

Oxidoreductase

Title:

Crystal structure of dox-p reductoisomerase fosmidomycin and magnesium

Structure:

1-deoxy-d-xylulose 5-phosphate reductoisomerase. Chain: a, b. Synonym: dxp reductoisomerase,1-deoxyxylulose-5-phosphate reductoisomerase,2-c-methyl-d-erythritol 4-phosphate synthase. Engineered: yes

Source:

Moraxella catarrhalis. Organism_taxid: 480. Gene: dxr, dr90_1378. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.20Å

R-factor:

0.226

R-free:

0.263

Authors:

R.W.Birkinshaw,R.L.Brady

Key ref:

R.W.Birkinshaw and r.l.brady Crystal structures of the moraxella catarrhalis dox-P reductoisomerase. To be published, .

Date:

10-May-15

Release date:

29-Jun-16

PROCHECK

	Headers

	References

Protein chains

A0A076U3E6 () -

Key:

Secondary structure



		Enzyme reactions

Enzyme class:

E.C.1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

2-C-methyl-D-erythritol 4-phosphate + NADP⁺ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H⁺

2-C-methyl-D-erythritol 4-phosphate	+	NADP(+)	=	1-deoxy-D-xylulose 5-phosphate	+	NADPH	+	H(+)

Cofactor:

Mg(2+) or cobalt cation or Mn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site