PDBsum entry 4zkl

Hydrolase

PDB id: 4zkl

Contents

Protein chains

112 a.a.

Ligands

AMP-JB6

AMP

Waters ×194

PDB id:

4zkl

Name:

Hydrolase

Title:

Crystal structure of human histidine triad nucleotide-binding protein 1 (hhint1) complexed with jb419 (ap4a analog)

Structure:

Histidine triad nucleotide-binding protein 1. Chain: a, b, c, d. Fragment: unp residues 1-126. Synonym: adenosine 5'-monophosphoramidase,protein kinasE C inhibitor 1,protein kinasE C-interacting protein 1,pkci-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hint1, hint, pkci1, prkcnh1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.34Å R-factor: 0.189 R-free: 0.239

Authors:

R.M.Dolot,R.Kaczmarek,A.Seda,A.Krakowiak,J.Baraniak,B.Nawrot

Key ref:

R.Dolot et al. (2016). Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A. Int J Biol Macromol, 87, 62-69. PubMed id: 26905466 DOI: 10.1016/j.ijbiomac.2016.02.047

Date:

30-Apr-15 Release date: 02-Mar-16

Protein chains

P49773  (HINT1_HUMAN) -  Adenosine 5'-monophosphoramidase HINT1 from Homo sapiens

Seq: 126 a.a.

Struc: 112 a.a.

Enzyme reactions

• Enzyme class 2: E.C.3.4.22.- - ?????
• Enzyme class 3: E.C.3.9.1.- - ?????

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

DOI no: 10.1016/j.ijbiomac.2016.02.047

Int J Biol Macromol 87:62-69 (2016)

PubMed id: 26905466

Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.

R.Dolot, R.Kaczmarek, A.Sęda, A.Krakowiak, J.Baraniak, B.Nawrot.

ABSTRACT

No abstract given.