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PDBsum entry 4zda
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Oxidoreductase
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PDB id
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4zda
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Crystal structure of isocitrate dehydrogenase in complex with isocitrate and mn from m. Smegmatis
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Structure:
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Isocitrate dehydrogenase (NADP) icd2. Chain: a, b, c, d, e, f. Synonym: isocitrate dehydrogenase,NADP-dependent. Engineered: yes
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Source:
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Mycobacterium smegmatis. Organism_taxid: 1772. Gene: icd2, msmeg_1654, msmei_1615. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.80Å
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R-factor:
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0.216
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R-free:
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0.257
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Authors:
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F.Pojer,P.Murima,J.D.Mckinney
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Key ref:
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F.Pojer
et al.
Crystal structure of isocitrate dehydrogenase in comp with isocitrate and mn from m. Smegmatis.
To be published,
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Date:
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17-Apr-15
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Release date:
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29-Jun-16
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PROCHECK
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Headers
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References
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A0QSZ3
(A0QSZ3_MYCS2) -
Isocitrate dehydrogenase [NADP] from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
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Seq:
Struc:
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743 a.a.
735 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.1.1.1.42
- isocitrate dehydrogenase (NADP(+)).
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Pathway:
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Citric acid cycle
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Reaction:
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D-threo-isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH
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D-threo-isocitrate
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+
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NADP(+)
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=
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2-oxoglutarate
Bound ligand (Het Group name = )
matches with 76.92% similarity
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+
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CO2
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+
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NADPH
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Cofactor:
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Mn(2+) or Mg(2+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
