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PDBsum entry 4z7m
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Hydrolase/hydrolase inhibitor
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PDB id
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4z7m
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Novel inhibitors of bacterial methionine aminopeptidase with broad- spectrum biochemical activity
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Structure:
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Methionine aminopeptidase. Chain: a, b. Synonym: metap, peptidase m, map. Engineered: yes
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Source:
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Escherichia coli. Organism_taxid: 562. Gene: map, z0178, ecs0170. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Resolution:
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1.43Å
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R-factor:
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0.254
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R-free:
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0.306
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Authors:
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J.A.Rose,S.D.Lahiri,D.C.Mckinney,R.Albert,M.Morningstar,A.B.Shapiro, S.F.Fisher,P.R.Fleming
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Key ref:
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J.A.Rose
et al.
Novel inhibitors of bacterial methionine aminopeptida broad-Spectrum biochemical activity.
To be published,
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Date:
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07-Apr-15
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Release date:
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13-Apr-16
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PROCHECK
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Headers
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References
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P0AE18
(MAP1_ECOLI) -
Methionine aminopeptidase from Escherichia coli (strain K12)
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Seq:
Struc:
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264 a.a.
261 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.4.11.18
- methionyl aminopeptidase.
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Reaction:
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Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
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Cofactor:
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Cobalt cation
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Links
