PDBsum entry 4z77

Immune system

PDB id: 4z77

Contents

Protein chains

277 a.a.

100 a.a.

Ligands

LEU-TYR-LEU-VAL-CYS-GLY-GLU-ARG-VAL ×2

GOL ×7

15P ×3

EDO ×12

SO4 ×6

Waters ×411

PDB id:

4z77

Name:

Immune system

Title:

Weak tcr binding to an unstable insulin epitope drives type 1 diabetes

Structure:

H-2 class i histocompatibility antigen, k-d alpha chain. Chain: a, d. Fragment: unp residues 22-296. Synonym: leukocyte antigen heavy chain, h-2k(d). Engineered: yes. Beta-2-microglobulin. Chain: b, e. Fragment: unp residues 21-119. Engineered: yes.

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: h2-k1, h2-k. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta. Homo sapiens. Human.

Resolution:

1.85Å R-factor: 0.209 R-free: 0.253

Authors:

P.J.Rizkallah,D.K.Cole

Key ref:

P.J.Rizkallah and d.k.cole Weak tcr binding to an unstable insulin epitope drive 1 diabetes. To be published, .

Date:

06-Apr-15 Release date: 24-Jun-15

Protein chains

P01902  (HA1D_MOUSE) -  H-2 class I histocompatibility antigen, K-D alpha chain from Mus musculus

Seq: 368 a.a.

Struc: 277 a.a.*

Protein chains

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)