PDBsum entry 4z50

Hydrolase

PDB id: 4z50

Contents

Protein chains

99 a.a.

Ligands

GOL ×2

Metals

_CL ×9

_NA ×4

Waters ×400

PDB id:

4z50

Name:

Hydrolase

Title:

Crystal structure of multidrug resistant HIV-1 protease clinical isolate pr20d25n with tucked flap

Structure:

Protease. Chain: a, b, c, d. Engineered: yes. Mutation: yes

Source:

Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.45Å R-factor: 0.141 R-free: 0.191

Authors:

J.Agniswamy,C.-H.Shen,I.T.Weber

Key ref:

C.H.Shen et al. (2015). Conformational variation of an extreme drug resistant mutant of HIV protease. J Mol Graph Model, 62, 87-96. PubMed id: 26397743 DOI: 10.1016/j.jmgm.2015.09.006

Date:

02-Apr-15 Release date: 14-Oct-15

Protein chains

Q0PQ60  (Q0PQ60_9HIV1) -  Protease (Fragment) from Human immunodeficiency virus 1

Seq: 99 a.a.

Struc: 99 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

DOI no: 10.1016/j.jmgm.2015.09.006

J Mol Graph Model 62:87-96 (2015)

PubMed id: 26397743

Conformational variation of an extreme drug resistant mutant of HIV protease.

C.H.Shen, Y.C.Chang, J.Agniswamy, R.W.Harrison, I.T.Weber.

ABSTRACT

No abstract given.