PDBsum entry 4z2l

Hydrolase/hydrolase inhibitor

PDB id: 4z2l

Contents

Protein chain

498 a.a.

Ligands

M6F

GOL ×4

Metals

_CL

Waters ×252

PDB id:

4z2l

Name:

Hydrolase/hydrolase inhibitor

Title:

Serratia marcescens chitinase b complexed with macrolide inhibitor 33

Structure:

Chitinase b. Chain: a. Engineered: yes

Source:

Serratia marcescens. Organism_taxid: 615. Gene: chib. Expressed in: escherichia coli dh5alpha. Expression_system_taxid: 668369.

Resolution:

2.30Å R-factor: 0.170 R-free: 0.207

Authors:

N.Maita,A.Sugawara,T.Sunazuka

Key ref:

A.Sugawara et al. (2015). Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase. J Med Chem, 58, 4984-4997. PubMed id: 26030312 DOI: 10.1021/acs.jmedchem.5b00175

Date:

30-Mar-15 Release date: 01-Jul-15

Protein chain

P11797  (CHIB_SERMA) -  Chitinase B from Serratia marcescens

Seq: 499 a.a.

Struc: 498 a.a.

Enzyme reactions

• Enzyme class: E.C.3.2.1.14 - chitinase.
• Reaction: Hydrolysis of the 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin.

DOI no: 10.1021/acs.jmedchem.5b00175

J Med Chem 58:4984-4997 (2015)

PubMed id: 26030312

Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.

A.Sugawara, N.Maita, H.Gouda, T.Yamamoto, T.Hirose, S.Kimura, Y.Saito, H.Nakano, T.Kasai, H.Nakano, K.Shiomi, S.Hirono, T.Watanabe, H.Taniguchi, S.Omura, T.Sunazuka.

ABSTRACT

No abstract given.