PDBsum entry 4z0e

Cell invasion

PDB id: 4z0e

Contents

Protein chains

270 a.a.

13 a.a.

Waters ×232

PDB id:

4z0e

Name:

Cell invasion

Title:

Crystal structure of fvo strain plasmodium falciparum ama1 in complex with the ron2hp [phe2038trn] peptide

Structure:

Apical membrane antigen 1. Chain: a. Fragment: unp residues 108-438. Engineered: yes. Rhoptry neck protein 2. Chain: c. Fragment: unp residues 1217-1229. Engineered: yes. Mutation: yes

Source:

Plasmodium falciparum vietnam oak-knoll (fvo). Organism_taxid: 1036723. Strain: fvo. Gene: pffvo_05649. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Plasmodium falciparum. Organism_taxid: 5833

Resolution:

1.90Å R-factor: 0.191 R-free: 0.229

Authors:

G.Wang,S.Mcgowan,R.S.Norton,M.J.Scanlon

Key ref:

G.Wang et al. (2016). Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction. J Mol Biol, 428, 3986-3998. PubMed id: 27422009 DOI: 10.1016/j.jmb.2016.07.001

Date:

26-Mar-15 Release date: 03-Aug-16

Protein chain

A0A024UZE1  (A0A024UZE1_PLAFA) -  Apical membrane antigen 1 from Plasmodium falciparum Vietnam Oak-Knoll

Seq: 622 a.a.

Struc: 270 a.a.

Protein chain

Q8IKV6  (Q8IKV6_PLAF7) -  Rhoptry neck protein 2 from Plasmodium falciparum (isolate 3D7)

Seq: 2189 a.a.

Struc: 13 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

DOI no: 10.1016/j.jmb.2016.07.001

J Mol Biol 428:3986-3998 (2016)

PubMed id: 27422009

Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.

G.Wang, N.Drinkwater, D.R.Drew, C.A.MacRaild, D.K.Chalmers, B.Mohanty, S.S.Lim, R.F.Anders, J.G.Beeson, P.E.Thompson, S.McGowan, J.S.Simpson, R.S.Norton, M.J.Scanlon.

ABSTRACT

No abstract given.