PDBsum entry 4yuk

Isomerase

PDB id: 4yuk

Contents

Protein chain

163 a.a.

Waters ×198

PDB id:

4yuk

Name:

Isomerase

Title:

Multiconformer synchrotron model of cypa at 260 k

Structure:

Peptidyl-prolyl cis-trans isomerase a. Chain: a. Synonym: ppiase a,cyclophilin a,cyclosporin a-binding protein, rotamase a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ppia, cypa. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.48Å R-factor: 0.132 R-free: 0.168

Authors:

D.A.Keedy,L.R.Kenner,M.Warkentin,R.A.Woldeyes,M.C.Thompson, A.S.Brewster,A.H.Van Benschoten,E.L.Baxter,J.B.Hopkins, M.Uervirojnangkoorn,S.E.Mcphillips,J.Song,R.A.Mori,J.M.Holton, W.I.Weis,A.T.Brunger,M.Soltis,H.Lemke,A.Gonzalez,N.K.Sauter, A.E.Cohen,H.Van Den Bedem,R.E.Thorne,J.S.Fraser

Key ref:

D.A.Keedy et al. (2015). Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography. Elife, 4, . PubMed id: 26422513 DOI: 10.7554/eLife.07574

Date:

18-Mar-15 Release date: 14-Oct-15

Protein chain

P62937  (PPIA_HUMAN) -  Peptidyl-prolyl cis-trans isomerase A from Homo sapiens

Seq: 165 a.a.

Struc: 163 a.a.

Enzyme reactions

• Enzyme class: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.7554/eLife.07574

Elife 4: (2015)

PubMed id: 26422513

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

D.A.Keedy, L.R.Kenner, M.Warkentin, R.A.Woldeyes, J.B.Hopkins, M.C.Thompson, A.S.Brewster, A.H.Van Benschoten, E.L.Baxter, M.Uervirojnangkoorn, S.E.McPhillips, J.Song, R.Alonso-Mori, J.M.Holton, W.I.Weis, A.T.Brunger, S.M.Soltis, H.Lemke, A.Gonzalez, N.K.Sauter, A.E.Cohen, H.van den Bedem, R.E.Thorne, J.S.Fraser.

ABSTRACT

No abstract given.