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PDBsum entry 4xvt

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protein ligands Protein-protein interface(s) links
Viral protein/immune system PDB id
4xvt

 

 

 

 

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Contents
Protein chains
341 a.a.
228 a.a.
208 a.a.
Ligands
NAG ×11
Waters ×625
PDB id:
4xvt
Name: Viral protein/immune system
Title: Crystal structure of HIV-1 93th057 coree gp120 with antibody 45- vrc01.H01+07.O-863513/45-vrc01.L01+07.O-110653 (vrc07_1995)
Structure: Envelope glycoprotein gp120 of HIV-1 clade a/e. Chain: g. Engineered: yes. Donor 45 45-vrc01.H01+07.O-863513/45-vrc01.L01+07.O-110653 (vrc07_1995) heavy chain. Chain: h. Engineered: yes. 45-vrc01.H01+07.O-863513/45-vrc01.L01+07.O-110653 (vrc07_1995) light chain.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f. Homo sapiens. Organism_taxid: 9606. Expression_system_cell_line: 293f
Resolution:
1.69Å     R-factor:   0.183     R-free:   0.222
Authors: M.G.Joyce,J.R.Mascola,P.D.Kwong
Key ref: X.Wu et al. (2015). Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell, 161, 470-485. PubMed id: 25865483 DOI: 10.1016/j.cell.2015.03.004
Date:
28-Jan-15     Release date:   15-Jul-15    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q0ED31  (Q0ED31_HV1) -  Envelope glycoprotein gp160 from Human immunodeficiency virus type 1
Seq:
Struc:
 
Seq:
Struc:
857 a.a.
341 a.a.*
Protein chain
No UniProt id for this chain
Struc: 228 a.a.
Protein chain
No UniProt id for this chain
Struc: 208 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 

 
DOI no: 10.1016/j.cell.2015.03.004 Cell 161:470-485 (2015)
PubMed id: 25865483  
 
 
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.
X.Wu, Z.Zhang, C.A.Schramm, M.G.Joyce, Y.D.Kwon, T.Zhou, Z.Sheng, B.Zhang, S.O'Dell, K.McKee, I.S.Georgiev, G.Y.Chuang, N.S.Longo, R.M.Lynch, K.O.Saunders, C.Soto, S.Srivatsan, Y.Yang, R.T.Bailer, M.K.Louder, J.C.Mullikin, M.Connors, P.D.Kwong, J.R.Mascola, L.Shapiro, B.Benjamin, R.Blakesley, G.Bouffard, S.Brooks, H.Coleman, M.Dekhtyar, M.Gregory, X.Guan, J.Gupta, J.Han, A.Hargrove, S.L.Ho, R.Legaspi, Q.Maduro, C.Masiello, B.Maskeri, J.McDowell, C.Montemayor, M.Park, N.Riebow, K.Schandler, B.Schmidt, C.Sison, M.Stantripop, J.Thomas, P.Thomas, M.Vemulapalli, A.Young.
 
  ABSTRACT  
 
No abstract given.

 

 

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