PDBsum entry 4xuf

Transferase/transferase inhibitor

PDB id: 4xuf

Contents

Protein chains

270 a.a.

Ligands

P30 ×2

Waters ×2

PDB id:

4xuf

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of the flt3 kinase domain bound to the inhibitor quizartinib (ac220)

Structure:

Receptor-type tyrosine-protein kinase flt3. Chain: a, b. Fragment: unp residues 600-710, 762-947. Synonym: fl cytokine receptor,fetal liver kinase-2,flk-2,fms-like tyrosine kinase 3,flt-3,stem cell tyrosine kinase 1,stk-1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: flt3, cd135, flk2, stk1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469

Resolution:

3.20Å R-factor: 0.299 R-free: 0.320

Authors:

J.A.Zorn,Q.Wang,E.Fujimura,T.Barros,J.Kuriyan

Key ref:

J.A.Zorn et al. (2015). Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220). Plos One, 10, e0121177. PubMed id: 25837374 DOI: 10.1371/journal.pone.0121177

Date:

25-Jan-15 Release date: 15-Apr-15

Protein chains

P36888  (FLT3_HUMAN) -  Receptor-type tyrosine-protein kinase FLT3 from Homo sapiens

Seq: 993 a.a.

Struc: 270 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1371/journal.pone.0121177

Plos One 10:e0121177 (2015)

PubMed id: 25837374

Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220).

J.A.Zorn, Q.Wang, E.Fujimura, T.Barros, J.Kuriyan.

ABSTRACT

No abstract given.