PDBsum entry 4xrq

Viral protein

PDB id: 4xrq

Contents

Protein chain

215 a.a.

Ligands

1B0

Waters ×93

PDB id:

4xrq

Name:

Viral protein

Title:

Disulfide stabilized HIV-1 ca hexamer 4mut (s41a, q67h, v165i, l172i) in complex with pf-3450074

Structure:

Capsid protein p24. Chain: a. Synonym: pr55gag, ca. Engineered: yes. Mutation: yes

Source:

Human immunodeficiency virus 1. HIV-1. Organism_taxid: 11676. Gene: gag. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.95Å R-factor: 0.191 R-free: 0.221

Authors:

A.J.Price,L.C.James

Key ref:

J.Zhou et al. (2015). HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry. J Virol, 89, 9068-9079. PubMed id: 26109731 DOI: 10.1128/JVI.00340-15

Date:

21-Jan-15 Release date: 15-Jul-15

Protein chain

P12493  (GAG_HV1N5) -  Gag polyprotein from Human immunodeficiency virus type 1 group M subtype B (isolate NY5)

Seq: 500 a.a.

Struc: 215 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

DOI no: 10.1128/JVI.00340-15

J Virol 89:9068-9079 (2015)

PubMed id: 26109731

HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.

J.Zhou, A.J.Price, U.D.Halambage, L.C.James, C.Aiken.

ABSTRACT

No abstract given.