PDBsum entry 4xhg

Transferase

PDB id: 4xhg

Contents

Protein chain

357 a.a.

Ligands

ADP

FMT

Waters ×285

PDB id:

4xhg

Name:

Transferase

Title:

Structure of c. Glabrata hrr25 bound to adp (formate condition)

Structure:

Similar to uniprot|p29295 saccharomyces cerevisiae ypl204w hrr25. Chain: a. Fragment: unp residues 1-403. Engineered: yes. Mutation: yes

Source:

Candida glabrata. Organism_taxid: 5478. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.15Å R-factor: 0.176 R-free: 0.216

Authors:

Q.Ye,K.D.Corbett

Key ref:

Q.Ye et al. (2016). Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. Embo J, 35, 2139-2151. PubMed id: 27491543 DOI: 10.15252/embj.201694082

Date:

05-Jan-15 Release date: 06-Jan-16

Protein chain

Q6FS46  (Q6FS46_CANGA) -  Candida glabrata strain CBS138 chromosome H complete sequence from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)

Seq: 495 a.a.

Struc: 357 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] (Bound ligand (Het Group name = ADP) corresponds exactly) + ADP + H(+)

L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] (Bound ligand (Het Group name = ADP) corresponds exactly) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.15252/embj.201694082

Embo J 35:2139-2151 (2016)

PubMed id: 27491543

Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator.

Q.Ye, S.N.Ur, T.Y.Su, K.D.Corbett.

ABSTRACT

No abstract given.