PDBsum entry 4xfa

Oxidoreductase

PDB id: 4xfa

Contents

Protein chain

186 a.a.

Ligands

HCS

Metals

_FE

Waters ×182

PDB id:

4xfa

Name:

Oxidoreductase

Title:

Cysteine dioxygenase variant - y157f at ph 8.0 in complex with homocysteine

Structure:

Cysteine dioxygenase type 1. Chain: a. Synonym: cysteine dioxygenase type i,cdo-i. Engineered: yes. Mutation: yes

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: cdo1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.65Å R-factor: 0.173 R-free: 0.210

Authors:

C.M.Driggers,P.A.Karplus

Key ref:

C.M.Driggers et al. Structures of mammalian cysteine dioxygenase variants missing the cys-Tyr crosslink. To be published, .

Date:

26-Dec-14 Release date: 24-Feb-16

Protein chain

P21816  (CDO1_RAT) -  Cysteine dioxygenase type 1 from Rattus norvegicus

Seq: 200 a.a.

Struc: 186 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.1.13.11.20 - cysteine dioxygenase.
• Reaction: L-cysteine + O2 = 3-sulfino-L-alanine + H⁺

L-cysteine (Bound ligand (Het Group name = HCS) matches with 66.67% similarity) + O2 = 3-sulfino-L-alanine + H(+)

• Cofactor: Fe(2+); NADH or NADPH

Molecule diagrams generated from .mol files obtained from the KEGG ftp site