PDBsum entry 4xaz

Hydrolase

PDB id: 4xaz

Contents

Protein chains

328 a.a.

Ligands

MPD

Metals

_ZN ×4

Waters ×581

PDB id:

4xaz

Name:

Hydrolase

Title:

Cycles of destabilization and repair underlie evolutionary transitions in enzymes

Structure:

Phosphotriesterase variant pte-r18. Chain: a, g. Engineered: yes

Source:

Brevundimonas diminuta. Organism_taxid: 293. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.55Å R-factor: 0.175 R-free: 0.206

Authors:

C.J.Jackson,E.Campbell,M.Kaltenbach,N.Tokuriki

Key ref:

E.Campbell et al. (2016). The role of protein dynamics in the evolution of new enzyme function. Nat Chem Biol, 12, 944-950. PubMed id: 27618189 DOI: 10.1038/nchembio.2175

Date:

16-Dec-14 Release date: 16-Dec-15

Protein chains

A0A060GYS7  (A0A060GYS7_BREDI) -  Phosphotriesterase variant PTE-R18 from Brevundimonas diminuta

Seq: 333 a.a.

Struc: 328 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

DOI no: 10.1038/nchembio.2175

Nat Chem Biol 12:944-950 (2016)

PubMed id: 27618189

The role of protein dynamics in the evolution of new enzyme function.

E.Campbell, M.Kaltenbach, G.J.Correy, P.D.Carr, B.T.Porebski, E.K.Livingstone, L.Afriat-Jurnou, A.M.Buckle, M.Weik, F.Hollfelder, N.Tokuriki, C.J.Jackson.

ABSTRACT

No abstract given.