PDBsum entry 4x80

Immune system

PDB id: 4x80

Contents

Protein chains

213 a.a.

223 a.a.

Waters ×27

PDB id:

4x80

Name:

Immune system

Title:

Crystal structure of murine 7b4 fab monoclonal antibody against adamts5

Structure:

Igg1 7b4 fab light chain. Chain: l. Engineered: yes. Igg1 7b4 fab heavy chain. Chain: h. Engineered: yes

Source:

Mus musculus. Organism_taxid: 10090. Cell_line: hybridoma. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell_line: hybridoma. Expression_system_cell_line: hybridoma

Resolution:

2.60Å R-factor: 0.222 R-free: 0.282

Authors:

J.Larkin,T.A.Lohr,L.Elefante,J.Shearin,R.Matico,J.-L.Su,Y.Xue,F.Liu, C.Genell,R.E.Miller,P.B.Tran,A.-M.Malfait,C.C.Maier,C.J.Matheny

Key ref:

J.Larkin et al. (2015). Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis Cartilage, 23, 1254-1266. PubMed id: 25800415 DOI: 10.1016/j.joca.2015.02.778

Date:

09-Dec-14 Release date: 08-Apr-15

Protein chain

No UniProt id for this chain

Struc: 213 a.a.

Protein chain

No UniProt id for this chain

Struc: 223 a.a.

DOI no: 10.1016/j.joca.2015.02.778

Osteoarthritis Cartilage 23:1254-1266 (2015)

PubMed id: 25800415

Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.

J.Larkin, T.A.Lohr, L.Elefante, J.Shearin, R.Matico, J.L.Su, Y.Xue, F.Liu, C.Genell, R.E.Miller, P.B.Tran, A.M.Malfait, C.C.Maier, C.J.Matheny.

ABSTRACT

No abstract given.