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PDBsum entry 4x2q
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Oxidoreductase
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PDB id
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4x2q
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Crystal structure of human aldehyde dehydrogenase, aldh1a2
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Structure:
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Retinal dehydrogenase 2. Chain: a, b, c, d. Synonym: raldh2,aldehyde dehydrogenase family 1 member a2, retinaldehyde-specific dehydrogenase type 2,raldh(ii). Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: aldh1a2, raldh2. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.94Å
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R-factor:
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0.268
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R-free:
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0.313
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Authors:
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R.E.Stenkamp,I.Le Trong,J.K.Amory,J.Paik,A.S.Goldstein
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Key ref:
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A.S.Goldstein
et al.
Synthesis and in vitro testing of bisdichloroacetyldi analogs for use as a reversible male contraceptive.
To be published,
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Date:
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26-Nov-14
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Release date:
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02-Dec-15
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PROCHECK
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Headers
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References
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O94788
(AL1A2_HUMAN) -
Retinal dehydrogenase 2 from Homo sapiens
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Seq:
Struc:
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518 a.a.
472 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.1.2.1.36
- retinal dehydrogenase.
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Reaction:
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retinal + NAD+ + H2O = retinoate + NADH + 2 H+
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retinal
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+
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NAD(+)
Bound ligand (Het Group name = )
matches with 61.36% similarity
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H2O
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=
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retinoate
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+
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NADH
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+
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2
×
H(+)
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Cofactor:
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FAD
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FAD
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
