PDBsum entry 4x1v

Signaling protein

PDB id: 4x1v

Contents

Protein chains

60 a.a.

14 a.a.

Waters ×68

PDB id:

4x1v

Name:

Signaling protein

Title:

Crystal structure of the 2nd sh3 domain from human cd2ap (cms) in complex with a proline-rich peptide (aa 76-91) from human arap1

Structure:

Cd2-associated protein. Chain: a. Fragment: unp residues 109-168. Synonym: adapter protein cms,cas ligand with multiple sh3 domains. Engineered: yes. Arf-gap with rho-gap domain, ank repeat and ph domain- containing protein 1. Chain: b. Fragment: unp residues 76-91.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cd2ap. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606

Resolution:

1.58Å R-factor: 0.162 R-free: 0.200

Authors:

E.Rouka,T.Krojer,F.Von Delft,S.Knapp,K.H.Kirsch,C.H.Arrowsmith, A.M.Edwards,C.Bountra,S.M.Feller,P.C.Simister

Key ref:

E.Rouka et al. Crystal structure of the 2nd sh3 domain from human cd (cms) in complex with a proline-Rich peptide (aa 76-9 human arap1. To be published, .

Date:

25-Nov-14 Release date: 17-Feb-16

Protein chain

Q9Y5K6  (CD2AP_HUMAN) -  CD2-associated protein from Homo sapiens

Seq: 639 a.a.

Struc: 60 a.a.

Protein chain

Q96P48  (ARAP1_HUMAN) -  Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 from Homo sapiens

Seq: 1450 a.a.

Struc: 14 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.?