PDBsum entry 4x1b

Metal transport

PDB id: 4x1b

Contents

Protein chain

650 a.a.

Ligands

MLI

GOL

Metals

_FE

Waters ×230

PDB id:

4x1b

Name:

Metal transport

Title:

Human serum transferrin with ferric ion bound at thE C-lobe only

Structure:

Serotransferrin. Chain: a. Synonym: fe-htf,transferrin,beta-1 metal-binding globulin, siderophilin

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organ: serum

Resolution:

2.45Å R-factor: 0.192 R-free: 0.227

Authors:

M.Wang,H.Zhang,H.Sun

Key ref:

M.Wang et al. (2015). "Anion clamp" allows flexible protein to impose coordination geometry on metal ions. Chem Commun (camb), 51, 7867-7870. PubMed id: 25854324 DOI: 10.1039/c4cc09642h

Date:

24-Nov-14 Release date: 08-Apr-15

Protein chain

P02787  (TRFE_HUMAN) -  Serotransferrin from Homo sapiens

Seq: 698 a.a.

Struc: 650 a.a.

DOI no: 10.1039/c4cc09642h

Chem Commun (camb) 51:7867-7870 (2015)

PubMed id: 25854324

"Anion clamp" allows flexible protein to impose coordination geometry on metal ions.

M.Wang, T.P.Lai, L.Wang, H.Zhang, N.Yang, P.J.Sadler, H.Sun.

ABSTRACT

X-ray crystal structures of human serum transferrin (77 kDa) with Yb(III) or Fe(III) bound to the C-lobe and malonate as the synergistic anion show that the large Yb(III) ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion.