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PDBsum entry 4w5c
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Hydrolase/hydrolase inhibitor
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PDB id
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4w5c
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Crystal structure analysis of cruzain with three fragments: 1 (n-(1h- benzimidazol-2-yl)-1,3-dimethyl-pyrazole-4-carboxamide), 6 (2-amino- 4,6-difluorobenzothiazole) and 9 (n-(1h-benzimidazol-2-yl)-3-(4- fluorophenyl)-1h-pyrazole-4-carboxamide).
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Structure:
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Cruzipain. Chain: a, b, c, d, e. Fragment: unp residues 122-337. Synonym: cruzaine,major cysteine proteinase. Engineered: yes. Mutation: yes
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Source:
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Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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3.27Å
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R-factor:
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0.195
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R-free:
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0.236
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Authors:
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A.Tochowicz,J.H.Mckerrow,C.S.Craik
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Key ref:
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A.Tochowicz
et al.
Applying fragments based- Drug design to identify mul binding modes on cysteine protease..
To be published,
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Date:
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17-Aug-14
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Release date:
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08-Apr-15
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PROCHECK
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Headers
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References
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P25779
(CYSP_TRYCR) -
Cruzipain from Trypanosoma cruzi
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Seq:
Struc:
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467 a.a.
215 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Links
