PDBsum entry 4uwb

Transferase

PDB id: 4uwb

Contents

Protein chains

299 a.a.

Ligands

EDO ×5

JVT ×2

SO4 ×2

Waters ×193

PDB id:

4uwb

Name:

Transferase

Title:

Fibroblast growth factor receptor 1 kinase in complex with jk-p5

Structure:

Fibroblast growth factor receptor 1. Chain: a, b. Fragment: kinase domain, residues 458-765. Synonym: fgfr-1, basic fibroblast growth factor receptor 1, bfgfr, bfgf-r-1, fms-like tyrosine kinase 2, flt-2, n-sam, proto-oncogenE C- fgr, fibroblast growth factor receptor 1 kinase. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.

Resolution:

2.31Å R-factor: 0.231 R-free: 0.272

Authors:

H.Beeston,J.Tucker,J.Kankanala

Key ref:

h.beeston (2021). Validation of IMS-MS as a screening tool to identify type II kinase inhibitors of FGFR1 kinase. Rapid Commun Mass Spectrom, 0, e9130. PubMed id: 34038603

Date:

11-Aug-14 Release date: 02-Sep-15

Protein chains

P11362  (FGFR1_HUMAN) -  Fibroblast growth factor receptor 1 from Homo sapiens

Seq: 822 a.a.

Struc: 299 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Rapid Commun Mass Spectrom 0:e9130 (2021)

PubMed id: 34038603

Validation of IMS-MS as a screening tool to identify type II kinase inhibitors of FGFR1 kinase.

h.beeston.

ABSTRACT

No abstract given.