PDBsum entry 4u1h

Immune system

PDB id: 4u1h

Contents

Protein chains

277 a.a.

100 a.a.

Ligands

THR-PRO-GLN-ASP-LEU-ASN-THR-MET-LEU

EDO ×11

GOL ×3

Waters ×314

PDB id:

4u1h

Name:

Immune system

Title:

Hla class i micropolymorphisms determine peptide-hla landscape and dictate differential HIV-1 escape through identical epitopes

Structure:

Hla class i histocompatibility antigen, b-7 alpha chain. Chain: a. Fragment: unp residues 25-300. Synonym: mhc class i antigen b 7. Engineered: yes. Beta-2-microglobulin. Chain: b. Engineered: yes. Gag protein.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-b, hlab. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes.

Resolution:

1.59Å R-factor: 0.165 R-free: 0.194

Authors:

P.J.Rizkallah,D.K.Cole,A.Fuller,A.K.Sewell

Key ref:

H.N.Kløverpris et al. (2015). A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology, 12, 20. PubMed id: 25808313 DOI: 10.1186/s12977-015-0149-5

Date:

15-Jul-14 Release date: 08-Apr-15

Protein chain

P01889  (1B07_HUMAN) -  HLA class I histocompatibility antigen, B alpha chain from Homo sapiens

Seq: 362 a.a.

Struc: 277 a.a.*

Protein chain

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1186/s12977-015-0149-5

Retrovirology 12:20 (2015)

PubMed id: 25808313

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.

H.N.Kløverpris, D.K.Cole, A.Fuller, J.Carlson, K.Beck, A.J.Schauenburg, P.J.Rizkallah, S.Buus, A.K.Sewell, P.Goulder.

ABSTRACT

No abstract given.