PDBsum entry 4py4

Transferase/transferase inhibitor

PDB id: 4py4

Contents

Protein chains

169 a.a.

176 a.a.

Ligands

XL2 ×2

Waters ×8

PDB id:

4py4

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of human poly(adp-ribose) polymerase 14, catalytic domain in complex with an inhibitor xl2

Structure:

Poly [adp-ribose] polymerase 14. Chain: a, b. Fragment: catalytic domain, unp residues 1613-1801. Synonym: parp-14, adp-ribosyltransferase diphtheria toxin-like 8, artd8, b aggressive lymphoma protein 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: parp14, bal2, kiaa1268. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.76Å R-factor: 0.204 R-free: 0.257

Authors:

J.Li,Y.Xu

Key ref:

J.Li and y.xu Crystal structure of human poly(ADP-Ribose) polymeras catalytic domain in complex with an inhibitor xl2. To be published, .

Date:

26-Mar-14 Release date: 01-Apr-15

Protein chain

Q460N5  (PAR14_HUMAN) -  Protein mono-ADP-ribosyltransferase PARP14 from Homo sapiens

Seq: 1801 a.a.

Struc: 169 a.a.

Protein chain

Q460N5  (PAR14_HUMAN) -  Protein mono-ADP-ribosyltransferase PARP14 from Homo sapiens

Seq: 1801 a.a.

Struc: 176 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.2.4.2.- - ?????