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PDBsum entry 4olv
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Viral protein/immune system
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PDB id
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4olv
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Contents |
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342 a.a.
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228 a.a.
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208 a.a.
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PDB id:
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| Name: |
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Viral protein/immune system
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Title:
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Crystal structure of antibody vrc07-g54f in complex with clade a/e 93th057 HIV-1 gp120 core
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Structure:
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Envelope glycoprotein gp160. Chain: g. Fragment: unp residues 43-122, 201-303, 325-486. Engineered: yes. Antigen binding fragment of heavy chain: antibody vrc01. Chain: h. Engineered: yes. Antigen binding fragment of light chain: antibody vrc01. Chain: l.
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Source:
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Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: 93th057. Gene: env, pol. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Other_details: HIV-1 gp120 with leader sequence. Homo sapiens.
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Resolution:
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2.50Å
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R-factor:
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0.206
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R-free:
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0.253
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Authors:
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Y.D.Kwon,P.D.Kwong
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Key ref:
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R.S.Rudicell
et al.
(2014).
Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo.
J Virol,
88,
12669-12682.
PubMed id:
DOI:
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Date:
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25-Jan-14
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Release date:
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03-Sep-14
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PROCHECK
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Headers
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References
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Q0ED31
(Q0ED31_HV1) -
Envelope glycoprotein gp160 from Human immunodeficiency virus type 1
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Seq:
Struc:
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857 a.a.
342 a.a.*
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DOI no:
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J Virol
88:12669-12682
(2014)
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PubMed id:
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Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo.
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R.S.Rudicell,
Y.D.Kwon,
S.Y.Ko,
A.Pegu,
M.K.Louder,
I.S.Georgiev,
X.Wu,
J.Zhu,
J.C.Boyington,
X.Chen,
W.Shi,
Z.Y.Yang,
N.A.Doria-Rose,
K.McKee,
S.O'Dell,
S.D.Schmidt,
G.Y.Chuang,
A.Druz,
C.Soto,
Y.Yang,
B.Zhang,
T.Zhou,
J.P.Todd,
K.E.Lloyd,
J.Eudailey,
K.E.Roberts,
B.R.Donald,
R.T.Bailer,
J.Ledgerwood,
J.C.Mullikin,
L.Shapiro,
R.A.Koup,
B.S.Graham,
M.C.Nason,
M.Connors,
B.F.Haynes,
S.S.Rao,
M.Roederer,
P.D.Kwong,
J.R.Mascola,
G.J.Nabel.
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ABSTRACT
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Links
