PDBsum entry 4nq5

Hydrolase/hydrolase inhibitor

PDB id: 4nq5

Contents

Protein chain

216 a.a.

Ligands

3C7

Metals

__K

_ZN ×2

Waters ×22

PDB id:

4nq5

Name:

Hydrolase/hydrolase inhibitor

Title:

Bacillus cereus zn-dependent metallo-beta-lactamase at ph 7 complexed with compound cs319

Structure:

Beta-lactamase 2. Chain: a. Fragment: unp residues 36-257. Synonym: beta-lactamase ii, cephalosporinase, penicillinase. Engineered: yes

Source:

Bacillus cereus. Organism_taxid: 1396. Gene: blm. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.29Å R-factor: 0.199 R-free: 0.254

Authors:

J.M.Gonzalez,M.M.Gonzalez,A.J.Vila

Key ref:

M.M.Gonzalez et al. Inhibition of metallo-Lactamases with bicyclic compou. To be published, .

Date:

23-Nov-13 Release date: 26-Nov-14

Protein chain

P04190  (BLA2_BACCE) -  Metallo-beta-lactamase type 2 from Bacillus cereus

Seq: 257 a.a.

Struc: 216 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)