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PDBsum entry 4mq4
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Transferase/transferase inhibitor
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PDB id
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4mq4
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Crystal structure of hpnmt in complex with bisubstrate inhibitor n-(3- ((((2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4- dihydroxytetrahydrofuran-2-yl)methyl)thio)propyl)-1,2,3,4- tetrahydroisoquinoline-3-carboxamide
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Structure:
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Phenylethanolamine n-methyltransferase. Chain: a, b. Synonym: pnmtase, noradrenaline n-methyltransferase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.20Å
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R-factor:
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0.183
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R-free:
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0.221
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Authors:
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A.G.Bart,E.E.Scott
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Key ref:
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A.G.Bart
and
e.e.scott
To be published.
To be published,
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Date:
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15-Sep-13
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Release date:
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15-Oct-14
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PROCHECK
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Headers
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References
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P11086
(PNMT_HUMAN) -
Phenylethanolamine N-methyltransferase from Homo sapiens
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Seq:
Struc:
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282 a.a.
264 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.1.1.28
- phenylethanolamine N-methyltransferase.
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Pathway:
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Dopa Biosynthesis
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Reaction:
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phenylethanolamine + S-adenosyl-L-methionine = N-methylphenylethanolamine + S-adenosyl-L-homocysteine + H+
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phenylethanolamine
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+
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S-adenosyl-L-methionine
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=
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N-methylphenylethanolamine
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+
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S-adenosyl-L-homocysteine
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+
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H(+)
Bound ligand (Het Group name = )
matches with 60.53% similarity
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
