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PDBsum entry 4mcp
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Hydrolase/hydrolase inhibitor
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PDB id
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4mcp
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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A high resolution structure of human glutamate carboxypeptidase ii (gcpii) in complex with folyl-gamma-l-glutamic acid (pteroyldi-gamma- l-glutamic acid)
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Structure:
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Glutamate carboxypeptidase 2. Chain: a. Fragment: unp residues 44-750. Synonym: cell growth-inhibiting gene 27 protein, folate hydrolase 1, folylpoly-gamma-glutamate carboxypeptidase, fgcp, glutamate carboxypeptidase ii, gcpii, membrane glutamate carboxypeptidase, mgcp, n-acetylated-alpha-linked acidic dipeptidase i, naaladase i, prostate-specific membrane antigen, psm, psma, pteroylpoly-gamma- glutamate carboxypeptidase.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: folh1, folh, naalad1, psm, psma, gig27. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
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Resolution:
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1.65Å
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R-factor:
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0.150
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R-free:
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0.164
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Authors:
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M.Navratil,C.Barinka,J.Lubkowski
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Key ref:
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M.Navrátil
et al.
(2014).
Structural and biochemical characterization of the folyl-poly-γ-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.
Febs J,
281,
3228-3242.
PubMed id:
DOI:
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Date:
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21-Aug-13
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Release date:
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18-Jun-14
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PROCHECK
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Headers
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References
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Q04609
(FOLH1_HUMAN) -
Glutamate carboxypeptidase 2 from Homo sapiens
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Seq:
Struc:
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750 a.a.
693 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.4.17.21
- glutamate carboxypeptidase Ii.
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Reaction:
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Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
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Cofactor:
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Zn(2+)
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DOI no:
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Febs J
281:3228-3242
(2014)
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PubMed id:
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Structural and biochemical characterization of the folyl-poly-γ-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.
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M.Navrátil,
J.Ptáček,
P.Šácha,
J.Starková,
J.Lubkowski,
C.Bařinka,
J.Konvalinka.
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ABSTRACT
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