PDBsum entry 4m7c

Hydrolase regulator

PDB id: 4m7c

Contents

Protein chains

195 a.a.

13 a.a.

Waters ×271

PDB id:

4m7c

Name:

Hydrolase regulator

Title:

Crystal structure of the trf2-binding motif of slx4 in complex with the trfh domain of trf2

Structure:

Telomeric repeat-binding factor 2. Chain: a, b. Fragment: trfh domain, unp residues 45-244. Synonym: ttaggg repeat-binding factor 2, telomeric DNA-binding protein. Engineered: yes. Peptide from structure-specific endonuclease subunit slx4. Chain: c, d. Fragment: trf2-binding motif, unp residues 1014-1025.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: terf2, trbf2, trf2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.05Å R-factor: 0.217 R-free: 0.262

Authors:

B.Wan,Y.Chen,J.Wu,Y.Liu,M.Lei

Key ref:

B.Wan et al. (2013). SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep, 4, 861-869. PubMed id: 24012755 DOI: 10.1016/j.celrep.2013.08.017

Date:

12-Aug-13 Release date: 25-Sep-13

Protein chains

Q15554  (TERF2_HUMAN) -  Telomeric repeat-binding factor 2 from Homo sapiens

Seq: 542 a.a.

Struc: 195 a.a.

Protein chains

Q8IY92  (SLX4_HUMAN) -  Structure-specific endonuclease subunit SLX4 from Homo sapiens

Seq: 1834 a.a.

Struc: 13 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.?

DOI no: 10.1016/j.celrep.2013.08.017

Cell Rep 4:861-869 (2013)

PubMed id: 24012755

SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres.

B.Wan, J.Yin, K.Horvath, J.Sarkar, Y.Chen, J.Wu, K.Wan, J.Lu, P.Gu, E.Y.Yu, N.F.Lue, S.Chang, Y.Liu, M.Lei.

ABSTRACT

No abstract given.