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PDBsum entry 4lmq
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Cell adhesion/immune system
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PDB id
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4lmq
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Contents |
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55 a.a.
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195 a.a.
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58 a.a.
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220 a.a.
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214 a.a.
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PDB id:
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| Name: |
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Cell adhesion/immune system
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Title:
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Development and preclinical characterization of a humanized antibody targeting cxcl12
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Structure:
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Stromal cell-derived factor 1. Chain: d, f. Fragment: unp residues 29-89. Synonym: sdf-1, hsdf-1, c-x-c motif chemokine 12, intercrine reduced in hepatomas, irh, hirh, pre-b cell growth-stimulating factor, pbsf, sdf-1-beta(3-72), sdf-1-alpha(3-67). Engineered: yes. Hu30d8 fab heavy chain. Chain: e, h.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cxcl12, sdf1, sdf1a, sdf1b. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Resolution:
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2.77Å
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R-factor:
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0.255
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R-free:
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0.301
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Authors:
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Z.Zhong,J.Wang,B.Li,H.Xiang,M.Ultsch,M.Coons,T.Wong,N.Y.Chiang, S.Clark,R.Clark,L.Quintana,P.Gribling,E.Suto,K.Barck,R.Corpuz,J.Yao, R.Takkar,W.P.Lee,L.A.Damico-Beyer,R.D.Carano,C.Adams,R.F.Kelley, W.Wang,N.Ferrara
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Key ref:
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C.Zhong
et al.
(2013).
Development and preclinical characterization of a humanized antibody targeting CXCL12.
Clin Cancer Res,
19,
4433-4445.
PubMed id:
DOI:
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Date:
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10-Jul-13
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Release date:
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14-Aug-13
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PROCHECK
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Headers
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References
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P48061
(SDF1_HUMAN) -
Stromal cell-derived factor 1 from Homo sapiens
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Seq:
Struc:
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93 a.a.
55 a.a.
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No UniProt id for this chain
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P48061
(SDF1_HUMAN) -
Stromal cell-derived factor 1 from Homo sapiens
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Seq:
Struc:
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93 a.a.
58 a.a.
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DOI no:
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Clin Cancer Res
19:4433-4445
(2013)
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PubMed id:
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Development and preclinical characterization of a humanized antibody targeting CXCL12.
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C.Zhong,
J.Wang,
B.Li,
H.Xiang,
M.Ultsch,
M.Coons,
T.Wong,
N.Y.Chiang,
S.Clark,
R.Clark,
L.Quintana,
P.Gribling,
E.Suto,
K.Barck,
R.Corpuz,
J.Yao,
R.Takkar,
W.P.Lee,
L.A.Damico-Beyer,
R.D.Carano,
C.Adams,
R.F.Kelley,
W.Wang,
N.Ferrara.
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ABSTRACT
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