PDBsum entry 4l93

Chaperone/chaperone inhibitor

PDB id: 4l93

Contents

Protein chains

207 a.a.

Ligands

S36 ×2

Waters ×183

PDB id:

4l93

Name:

Chaperone/chaperone inhibitor

Title:

Crystal structure of human hsp90 with s36

Structure:

Heat shock protein hsp 90-alpha. Chain: a, b. Fragment: unp residues 9-236. Synonym: heat shock 86 kda, hsp 86, hsp86, renal carcinoma antigen ny-ren-38. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hsp90aa1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.85Å R-factor: 0.225 R-free: 0.260

Authors:

J.Li,J.Ren,M.Yang,B.Xiong,J.He

Key ref:

J.Li et al. Crystal structure of human hsp90 with s36. To be published, .

Date:

18-Jun-13 Release date: 18-Jun-14

Protein chains

P07900  (HS90A_HUMAN) -  Heat shock protein HSP 90-alpha from Homo sapiens

Seq: 732 a.a.

Struc: 207 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.4.10 - non-chaperonin molecular chaperone ATPase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site