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PDBsum entry 4l7h
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Hydrolase/hydrolase inhibitor
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PDB id
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4l7h
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxy-benzylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against beta-secretase-1 (bace-1)
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Structure:
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Beta-secretase 1. Chain: a. Fragment: unp residues 57-453. Synonym: aspartyl protease 2, asp2, asp 2, beta-site amyloid precursor protein cleaving enzyme 1, beta-site app cleaving enzyme 1, memapsin-2, membrane-associated aspartic protease 2. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.85Å
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R-factor:
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0.189
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R-free:
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0.227
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Authors:
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M.P.Huestis,W.Liu,M.Volgraf,H.E.Purkey,W.Wang,C.Yu,P.Wu,D.Smith, G.Vigers,D.Dutcher,M.K.Geck Do,K.W.Hunt,M.Siu
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Key ref:
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M.P.Huestis
et al.
Diethylaminosulfur trifluoride-Mediated intramolecula cyclization of 2-Hydroxycycloalkylureas to fused bicy aminooxazoline compounds and evaluation of their bioc activity against β.
Tetrahedron lett,
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Date:
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13-Jun-13
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Release date:
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18-Sep-13
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PROCHECK
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Headers
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References
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P56817
(BACE1_HUMAN) -
Beta-secretase 1 from Homo sapiens
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Seq:
Struc:
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501 a.a.
374 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Links
