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PDBsum entry 4l7e
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Signaling protein
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PDB id
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4l7e
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PDB id:
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| Name: |
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Signaling protein
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Title:
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Three dimensional structure of mutant d78a of human hd domain- containing protein 2, genomics consortium (nesg) target hr6723
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Structure:
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Hd domain-containing protein 2. Chain: a, b. Synonym: hepatitis c virus ns5a-transactivated protein 2, hcv ns5a- transactivated protein 2. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: hddc2, c6orf74, ns5atp2, cgi-130. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.23Å
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R-factor:
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0.176
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R-free:
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0.215
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Authors:
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A.Kuzin,M.Su,A.Yakunin,N.Beloglazova,J.Seetharaman,M.Maglaqui,R.Xiao, D.Lee,G.Brown,R.Flick,J.K.Everett,T.B.Acton,G.T.Montelione,J.F.Hunt, L.Tong,Northeast Structural Genomics Consortium (Nesg)
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Key ref:
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A.Kuzin
et al.
Northeast structural genomics consortium target hr672.
To be published,
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Date:
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13-Jun-13
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Release date:
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24-Jul-13
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PROCHECK
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Headers
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References
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Q7Z4H3
(HDDC2_HUMAN) -
5'-deoxynucleotidase HDDC2 from Homo sapiens
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Seq:
Struc:
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204 a.a.
187 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.1.3.89
- 5'-deoxynucleotidase.
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Reaction:
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a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate
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2'-deoxyribonucleoside 5'-phosphate
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+
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H2O
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=
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2'-deoxyribonucleoside
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+
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phosphate
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Cofactor:
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Cobalt cation
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
