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PDBsum entry 4l3c
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protein ligands metals Protein-protein interface(s) links
Immune system PDB id
4l3c

 

 

 

 

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Contents
Protein chains
(+ 8 more) 276 a.a.
(+ 8 more) 100 a.a.
Ligands
TYR-LEU-LEU-MET-
TRP-ILE-THR-GLN-
VAL ×14
GOL ×20
Metals
_CL ×38
Waters ×134
PDB id:
4l3c
Name: Immune system
Title: Structure of hla-a2 in complex with d76n b2m mutant and ny-eso1 double mutant
Structure: Hla class i histocompatibility antigen, a-2 alpha chain. Chain: a, c, e, g, i, k, m, o, q, s, u, w, y, a. Fragment: unp residues 25-300. Synonym: mhc class i antigen a 2. Engineered: yes. Beta-2-microglobulin. Chain: b, d, f, h, j, l, n, p, r, t, v, x, z, b. Fragment: unp residues 21-119. Synonym: beta-2-microglobulin form pi 5.3.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa, hla_a0201. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: b2m, cdabp0092, hdcma22p, nm_004048. Expression_system_taxid: 511693. Synthetic: yes
Resolution:
2.64Å     R-factor:   0.200     R-free:   0.218
Authors: L.Halabelian,S.Giorgetti,V.Bellotti,M.Bolognesi,S.Ricagno
Key ref: L.Halabelian et al. (2014). Class I major histocompatibility complex, the trojan horse for secretion of amyloidogenic β2-microglobulin. J Biol Chem, 289, 3318-3327. PubMed id: 24338476 DOI: 10.1074/jbc.M113.524157
Date:
05-Jun-13     Release date:   25-Dec-13    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens
Seq:
Struc: 		365 a.a.
276 a.a.*
Protein chains
Pfam   ArchSchema ?
P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens
Seq:
Struc: 		119 a.a.
100 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 22 residue positions (black crosses)

 

 
DOI no: 10.1074/jbc.M113.524157 J Biol Chem 289:3318-3327 (2014)
PubMed id: 24338476  
 
 
Class I major histocompatibility complex, the trojan horse for secretion of amyloidogenic β2-microglobulin.
L.Halabelian, S.Ricagno, S.Giorgetti, C.Santambrogio, A.Barbiroli, S.Pellegrino, A.Achour, R.Grandori, L.Marchese, S.Raimondi, P.P.Mangione, G.Esposito, R.Al-Shawi, J.P.Simons, I.Speck, M.Stoppini, M.Bolognesi, V.Bellotti.
 
  ABSTRACT  
 
No abstract given.

 

 

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