PDBsum entry 4kgo

Immune system

PDB id: 4kgo

Contents

Protein chains

203 a.a.

183 a.a.

PDB id:

4kgo

Name:

Immune system

Title:

Crystal structure of double leucine to methionine mutant human splunc1 lacking the secretion signal sequence

Structure:

Bpi fold-containing family a member 1. Chain: b, a. Fragment: unp residues 19-256. Synonym: lung-specific protein x, nasopharyngeal carcinoma-related protein, palate lung and nasal epithelium clone protein, secretory protein in upper respiratory tracts, tracheal epithelium-enriched protein, von ebner protein hl. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: bpifa1, lunx, nasg, plunc, spurt, unq787/pro1606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

3.19Å R-factor: 0.230 R-free: 0.256

Authors:

L.Betts,W.G.Walton

Key ref:

A.L.Garland et al. (2013). Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proc Natl Acad Sci U S A, 110, 15973-15978. PubMed id: 24043776 DOI: 10.1073/pnas.1311999110

Date:

29-Apr-13 Release date: 25-Sep-13

Protein chain

Q9NP55  (BPIA1_HUMAN) -  BPI fold-containing family A member 1 from Homo sapiens

Seq: 256 a.a.

Struc: 203 a.a.*

Protein chain

Q9NP55  (BPIA1_HUMAN) -  BPI fold-containing family A member 1 from Homo sapiens

Seq: 256 a.a.

Struc: 183 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

DOI no: 10.1073/pnas.1311999110

Proc Natl Acad Sci U S A 110:15973-15978 (2013)

PubMed id: 24043776

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.

A.L.Garland, W.G.Walton, R.D.Coakley, C.D.Tan, R.C.Gilmore, C.A.Hobbs, A.Tripathy, L.A.Clunes, S.Bencharit, M.J.Stutts, L.Betts, M.R.Redinbo, R.Tarran.

ABSTRACT

No abstract given.