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PDBsum entry 4js9
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Oxidoreductase
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PDB id
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4js9
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Structural characterization of inducible nitric oxide synthase substituted with mesoheme
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Structure:
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Nitric oxide synthase, inducible. Chain: a, b. Fragment: oxygenase domain 66-496. Synonym: inducible no synthase, inducible nos, inos, macrophage nos, mac-nos, nos type ii, peptidyl-cysteine s-nitrosylase nos2. Engineered: yes
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Source:
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Mus musculus. Mouse. Organism_taxid: 10090. Gene: inosl, nos2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.78Å
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R-factor:
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0.252
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R-free:
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0.290
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Authors:
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L.Hannibal,R.C.Page,K.Bolisetty,Z.Yu,S.Misra,D.J.Stuehr
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Key ref:
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L.Hannibal
et al.
Kinetic and structural characterization of inducible oxide synthase substituted with mesoheme.
To be published,
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Date:
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22-Mar-13
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Release date:
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23-Apr-14
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PROCHECK
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Headers
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References
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P29477
(NOS2_MOUSE) -
Nitric oxide synthase, inducible from Mus musculus
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Seq:
Struc:
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1144 a.a.
405 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.1.14.13.39
- nitric-oxide synthase (NADPH).
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Reaction:
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2 L-arginine + 3 NADPH + 4 O2 + H+ = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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2
×
L-arginine
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+
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3
×
NADPH
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+
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4
×
O2
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+
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H(+)
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=
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2
×
L-citrulline
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+
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2
×
nitric oxide
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+
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3
×
NADP(+)
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+
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4
×
H2O
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
