PDBsum entry 4js8

Transferase/transferase inhibitor

PDB id: 4js8

Contents

Protein chain

261 a.a.

Ligands

1PF

SO4 ×2

PEG ×2

GOL ×2

Waters ×73

PDB id:

4js8

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of ttk kinase domain with an inhibitor: 401348

Structure:

Dual specificity protein kinase ttk. Chain: a. Fragment: kinase domain. Synonym: phosphotyrosine picked threonine-protein kinase, pyt. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ttk, mps1, mps1l1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.94Å R-factor: 0.232 R-free: 0.253

Authors:

W.Qiu,A.N.Plotnikov,O.Plotnikova,M.Feher,D.E.Awrey,N.Y.Chirgadze

Key ref:

W.Qiu et al. Crystal structure of ttk kinase domain with an inhibi 401348. To be published, .

Date:

22-Mar-13 Release date: 26-Mar-14

Protein chain

P33981  (TTK_HUMAN) -  Dual specificity protein kinase TTK from Homo sapiens

Seq: 857 a.a.

Struc: 261 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.12.1 - dual-specificity kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺
  3. L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site