PDBsum entry 4jlu

Antitumor protein/signaling protein

PDB id: 4jlu

Contents

Protein chains

211 a.a.

11 a.a.

PDB id:

4jlu

Name:

Antitumor protein/signaling protein

Title:

Crystal structure of brca1 brct with doubly phosphorylated abraxas

Structure:

Breast cancer type 1 susceptibility protein. Chain: a. Fragment: unp residues 1649-1859. Synonym: ring finger protein 53. Engineered: yes. Brca1-a complex subunit abraxas. Chain: b. Fragment: unp residues 399-409. Synonym: coiled-coil domain-containing protein 98, protein fam175a.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: brca1, rnf53. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized.

Resolution:

3.50Å R-factor: 0.300 R-free: 0.327

Authors:

D.Badgujar,A.K.Varma

Key ref:

D.Badgujar and a.k.varma Crystal structure of brca1 brct with doubly phosphory abraxas. To be published, .

Date:

13-Mar-13 Release date: 10-Sep-14

Protein chain

P38398  (BRCA1_HUMAN) -  Breast cancer type 1 susceptibility protein from Homo sapiens

Seq: 1863 a.a.

Struc: 211 a.a.

Protein chain

Q6UWZ7  (ABRX1_HUMAN) -  BRCA1-A complex subunit Abraxas 1 from Homo sapiens

Seq: 409 a.a.

Struc: 11 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine