PDBsum entry 4jfh

Immune system

PDB id: 4jfh

Contents

Protein chains

200 a.a.

244 a.a.

Ligands

EDO ×5

GOL

SO4 ×3

Waters ×161

PDB id:

4jfh

Name:

Immune system

Title:

High affinity alpha24-beta17 t cell receptor for a2 hla-melanoma peptide complex

Structure:

Alpha24 tcr allele. Chain: d. Engineered: yes. Beta17 tcr allele. Chain: e. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.40Å R-factor: 0.203 R-free: 0.247

Authors:

P.J.Rizkallah,D.K.Cole,F.Madura,A.K.Sewell

Key ref:

F.Madura et al. (2013). T-cell receptor specificity maintained by altered thermodynamics. J Biol Chem, 288, 18766-18775. PubMed id: 23698002 DOI: 10.1074/jbc.M113.464560

Date:

28-Feb-13 Release date: 29-May-13

Protein chain

P01848  (TCA_HUMAN) -  T cell receptor alpha chain constant from Homo sapiens

Seq: 140 a.a.

Struc: 200 a.a.*

Protein chain

P01850  (TRBC1_HUMAN) -  T cell receptor beta constant 1 from Homo sapiens

Seq: 176 a.a.

Struc: 244 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

DOI no: 10.1074/jbc.M113.464560

J Biol Chem 288:18766-18775 (2013)

PubMed id: 23698002

T-cell receptor specificity maintained by altered thermodynamics.

F.Madura, P.J.Rizkallah, K.M.Miles, C.J.Holland, A.M.Bulek, A.Fuller, A.J.Schauenburg, J.J.Miles, N.Liddy, M.Sami, Y.Li, M.Hossain, B.M.Baker, B.K.Jakobsen, A.K.Sewell, D.K.Cole.

ABSTRACT

No abstract given.