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PDBsum entry 4jff
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protein ligands Protein-protein interface(s) links
Immune system PDB id
4jff

 

 

 

 

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Contents
Protein chains
276 a.a.
100 a.a.
197 a.a.
245 a.a.
Ligands
GLU-LEU-ALA-GLY-
ILE-GLY-ILE-LEU-
THR-VAL
EPE ×2
SO4 ×7
Waters ×159
PDB id:
4jff
Name: Immune system
Title: Preservation of peptide specificity during tcr-mhc contact dominated affinity enhancement of a melanoma-specific tcr
Structure: Hla class i histocompatibility antigen, a-2 alpha chain. Chain: a. Synonym: mhc class i antigen a 2. Engineered: yes. Beta-2-microglobulin. Chain: b. Synonym: beta-2-microglobulin form pi 5.3. Engineered: yes. Melanoma motif.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes.
Resolution:
2.43Å     R-factor:   0.213     R-free:   0.263
Authors: P.J.Rizkallah,D.K.Cole,F.Madura,A.K.Sewell
Key ref: F.Madura et al. (2013). T-cell receptor specificity maintained by altered thermodynamics. J Biol Chem, 288, 18766-18775. PubMed id: 23698002 DOI: 10.1074/jbc.M113.464560
Date:
28-Feb-13     Release date:   29-May-13    
PROCHECK
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 Headers
 References

Protein chain
P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens
Seq:
Struc: 		365 a.a.
276 a.a.*
Protein chain
P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens
Seq:
Struc: 		119 a.a.
100 a.a.*
Protein chain
P01848  (TCA_HUMAN) -  T cell receptor alpha chain constant from Homo sapiens
Seq:
Struc: 		140 a.a.
197 a.a.*
Protein chain
P01850  (TRBC1_HUMAN) -  T cell receptor beta constant 1 from Homo sapiens
Seq:
Struc: 		176 a.a.
245 a.a.*
Key:    Secondary structure  CATH domain
* PDB and UniProt seqs differ at 28 residue positions (black crosses)

 

 
DOI no: 10.1074/jbc.M113.464560 J Biol Chem 288:18766-18775 (2013)
PubMed id: 23698002  
 
 
T-cell receptor specificity maintained by altered thermodynamics.
F.Madura, P.J.Rizkallah, K.M.Miles, C.J.Holland, A.M.Bulek, A.Fuller, A.J.Schauenburg, J.J.Miles, N.Liddy, M.Sami, Y.Li, M.Hossain, B.M.Baker, B.K.Jakobsen, A.K.Sewell, D.K.Cole.
 
  ABSTRACT  
 
No abstract given.

 

 

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