PDBsum entry 4j9h

Transferase/unknown function

PDB id: 4j9h

Contents

Protein chains

59 a.a.

56 a.a.

(+ 0 more) 11 a.a.

Ligands

SO4

Waters ×384

PDB id:

4j9h

Name:

Transferase/unknown function

Title:

Crystal structure of the abl-sh3 domain complexed with the designed high-affinity peptide ligand p7 at ph 8

Structure:

Tyrosine-protein kinase abl1. Chain: a, b, c, d, e, f. Fragment: sh3 domain. Synonym: abelson murine leukemia viral oncogene homolog 1, abelson tyrosine-protein kinase 1, proto-oncogenE C-abl, p150. Engineered: yes. P7. Chain: g, h, i, j, k, l. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence has been optimized to increase the

Resolution:

1.70Å R-factor: 0.161 R-free: 0.209

Authors:

A.Camara-Artigas

Key ref:

A.Camara-Artigas Crystal structure of the abl-Sh3 domain complexed wit designed high-Affinity peptide ligand p7. To be published, .

Date:

16-Feb-13 Release date: 29-Jan-14

Protein chains

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 59 a.a.

Protein chains

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 56 a.a.

Protein chains

No UniProt id for this chain

Struc: 10 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C, D, E, F: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site