PDBsum entry 4j9b

Transferase

PDB id: 4j9b

Contents

Protein chain

58 a.a.

Ligands

PEG ×2

Waters ×39

PDB id:

4j9b

Name:

Transferase

Title:

Crystal structure of the abl-sh3 domain h59q-n96t mutant

Structure:

Tyrosine-protein kinase abl1. Chain: a. Fragment: sh3 domain (unp residues 60-121). Synonym: abelson murine leukemia viral oncogene homolog 1, abelson tyrosine-protein kinase 1, proto-oncogenE C-abl, p150. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.70Å R-factor: 0.167 R-free: 0.213

Authors:

A.Camara-Artigas

Key ref:

A.Camara-Artigas Crystal structure of the abl-Sh3 domain h59q-N96t mut. To be published, .

Date:

16-Feb-13 Release date: 29-Jan-14

Protein chain

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 58 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site