PDBsum entry 4ixc

Transferase/transferase inhibitor

PDB id: 4ixc

Contents

Protein chain

443 a.a.

Ligands

GLC

1JD

Metals

_NA

Waters ×252

PDB id:

4ixc

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of human glucokinase in complex with a small molecule activator.

Structure:

Glucokinase isoform 3. Chain: a. Fragment: glucokinase. Synonym: hexokinase type iv, hk iv, hexokinase-4, hk4, hexokinase-d. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.00Å R-factor: 0.190 R-free: 0.249

Authors:

D.J.Ogg,D.Hargreaves,S.Gerhardt

Key ref:

M.J.Waring et al. Matched triplicate design sets in the optimisation of glucokinase activators maximising medicinal chemistry information content. To be published, .

Date:

25-Jan-13 Release date: 24-Apr-13

Protein chain

P35557  (HXK4_HUMAN) -  Hexokinase-4 from Homo sapiens

Seq: 465 a.a.

Struc: 443 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.1.1 - hexokinase.
• Reaction: a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H⁺

D-hexose (Bound ligand (Het Group name = GLC) corresponds exactly) + ATP = D-hexose 6-phosphate + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site