PDBsum entry 4ijh

DNA binding protein/inhibitor

PDB id: 4ijh

Contents

Protein chain

123 a.a.

Ligands

1EJ ×5

Waters ×133

PDB id:

4ijh

Name:

DNA binding protein/inhibitor

Title:

Fragment-based discovery of protein-protein interaction inhibitors of replication protein a

Structure:

Replication protein a 70 kda DNA-binding subunit. Chain: a. Fragment: n-terminal domain (unp residues 1-120). Synonym: rp-a p70, replication factor a protein 1, rf-a protein 1, single-stranded DNA-binding protein. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: repa1, rpa1, rpa70. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.50Å R-factor: 0.151 R-free: 0.189

Authors:

M.D.Feldkamp,J.D.Patrone,J.P.Kennedy,A.O.Frank,B.Vangamudi,N.F.Pelz, O.W.Rossanese,A.G.Waterson,S.W.Fesik,W.J.Chazin

Key ref:

J.D.Patrone et al. (2013). Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. Acs Med Chem Lett, 4, 601-605. PubMed id: 23914285 DOI: 10.1021/ml400032y

Date:

21-Dec-12 Release date: 14-Aug-13

Protein chain

P27694  (RFA1_HUMAN) -  Replication protein A 70 kDa DNA-binding subunit from Homo sapiens

Seq: 616 a.a.

Struc: 123 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

DOI no: 10.1021/ml400032y

Acs Med Chem Lett 4:601-605 (2013)

PubMed id: 23914285

Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.

J.D.Patrone, J.P.Kennedy, A.O.Frank, M.D.Feldkamp, B.Vangamudi, N.F.Pelz, O.W.Rossanese, A.G.Waterson, W.J.Chazin, S.W.Fesik.

ABSTRACT

No abstract given.