PDBsum entry 4hqp

Protein binding

PDB id: 4hqp

Contents

Protein chains

202 a.a.

73 a.a.

Ligands

NAG-NAG

NAG ×6

PDB id:

4hqp

Name:

Protein binding

Title:

Alpha7 nicotinic receptor chimera and its complex with alpha bungarotoxin

Structure:

Alpha7 nicotinic receptor chimera. Chain: a, b, c, d, e. Engineered: yes. Alpha-bungarotoxin isoform v31. Chain: f, g, h, i, j. Synonym: alpha-btx v31, alpha-bgt(v31), bgtx v31, long neurotoxin 1

Source:

Homo sapiens, lymnaea stagnalis. Human, great pond snail. Organism_taxid: 9606, 6523. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Bungarus multicinctus. Many-banded krait. Organism_taxid: 8616. Organ: venom

Resolution:

3.51Å R-factor: 0.311 R-free: 0.321

Authors:

S.X.Li,K.Cheng,R.Gomoto,N.Bren,S.Huang,S.Sine,L.Chen

Key ref:

S.X.Li et al. Structural principles for alpha-Neurotoxin binding to selectivity among nicotinic receptors. To be published, .

Date:

25-Oct-12 Release date: 17-Jul-13

Protein chains

P58154  (ACHP_LYMST) -  Acetylcholine-binding protein from Lymnaea stagnalis

Seq: 229 a.a.

Struc: 202 a.a.*

Protein chains

P60616  (3L21V_BUNMU) -  Alpha-bungarotoxin isoform V31 from Bungarus multicinctus

Seq: 95 a.a.

Struc: 73 a.a.

* PDB and UniProt seqs differ at 77 residue positions (black crosses)