PDBsum entry 4fv6

Transferase

PDB id: 4fv6

Contents

Protein chain

332 a.a.

Ligands

E57

SO4 ×3

EDO

Waters ×77

PDB id:

4fv6

Name:

Transferase

Title:

Crystal structure of the erk2 complexed with e57

Structure:

Mitogen-activated protein kinase 1. Chain: a. Synonym: map kinase 1, mapk 1, ert1, extracellular signal-regulated kinase 2, erk-2, map kinase isoform p42, p42-mapk, mitogen-activated protein kinase 2, map kinase 2, mapk 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: erk2, mapk1, prkm1, prkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.50Å R-factor: 0.222 R-free: 0.249

Authors:

Y.N.Kang,J.A.Stuckey,X.Xie

Key ref:

Y.N.Kang et al. Crystal structure of the erk2 complexed with e57. To be published, .

Date:

29-Jun-12 Release date: 29-Aug-12

Protein chain

P28482  (MK01_HUMAN) -  Mitogen-activated protein kinase 1 from Homo sapiens

Seq: 360 a.a.

Struc: 332 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site